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Parathyroid hormone and genetic hypertension
1Biologie Cellulaire & Physiopathologie Digestives, INSERM U61, Strasbourg, France.
International Journal of Cardiology
|June 1, 1992
Summary
Parathyroid hormone may contribute to genetic hypertension by affecting calcium metabolism. Calcium supplements and parathyroid gland removal reduced blood pressure in studies, suggesting a link.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Research
Background:
- Genetic hypertension is linked to calcium metabolism abnormalities.
- Elevated parathyroid hormone and depressed serum ionized calcium are observed.
Purpose of the Study:
- To review the role of calcium metabolism and the endocrine system in genetic hypertension.
- To discuss mechanisms of blood pressure reduction via dietary supplements and parathyroidectomy.
Main Methods:
- Review of existing research on genetic hypertension, calcium metabolism, and parathyroid hormone.
- Analysis of studies involving calcium supplementation and parathyroidectomy in hypertensive models.
Main Results:
- Calcium supplementation normalized calcium metabolism and lowered blood pressure.
- Parathyroidectomy attenuated blood pressure increase in genetic hypertensive rats.
Conclusions:
- Parathyroid hormone may play a permissive role in the development of genetic hypertension.
- Abnormalities in calcium and parathyroid hormone are implicated in hypertension etiology.