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Neonatal cow milk sensitization in 143 case-reports: role of early exposure to cow's milk formula

A Cantani1, M Micera

  • 1Department of Pediatrics, Allergy and Clinical Immunology Division, La Sapienza University--Rome, Italy.

European Review for Medical and Pharmacological Sciences
|September 1, 2005
PubMed

Insights

Cow's milk allergy (CMA) in infants often presents with immediate symptoms upon first exposure. Neonatal nursery exposure to cow's milk (CM) formulas may be particularly sensitizing, even in small doses.

Area of Science:

  • Pediatrics
  • Immunology
  • Allergy

Background:

  • Cow's milk allergy (CMA) is a common infant condition.
  • Early-life symptoms of CMA are not fully understood.
  • Pediatricians frequently encounter infants with suspected CMA.

Purpose of the Study:

  • To determine the prevalence of severe reactions to cow's milk (CM).
  • To identify clinical manifestations of CM administration in nurseries.

Main Methods:

  • Prospective study of 143 infants diagnosed with CMA.

Main Results:

  • All infants experienced immediate symptoms upon initial CM introduction (ages 1-8 months, median 4 months).
  • Sensitization likely occurred within the first days of life.
  • Exposure to CM formulas in neonatal nurseries appeared particularly sensitizing.

Conclusions:

  • Small allergen doses may be more sensitizing than larger ones.
  • Oral antigen administration during the neonatal period has significant immunological effects.
  • Transmission of allergens via breast milk (BM) to nursing infants is a potential concern.
Abstract

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