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Updated: Jul 16, 2026

Fertility Preservation in Patients with Severe Ovarian Dysfunction
Published on: March 25, 2021
[Prevalence of thrombophilia in patients with severe ovarian hyperstimulation syndrome]
S Machac1, M Procházka, M Lubuský
1Klinika pro lécbu neplodnosti Unica, Brno.
Objective:
To determine the prevalence of markers of thrombophilia in patients with severe form of ovarian hyperstimulation syndrome
Design:
Retrospective case - control study
Setting:
Unica, Institute for Reproductive Medicine, Brno
Methods:
Blood samples to test for markers of thrombophilia were obtained from 30 patients who were hospitalised for severe OHSS. Results were compared with two control groups.
Results:
None of the patients with severe OHSS had antithrombin, protein C or protein S deficiencies. We also did not observe increased prothrombin level. Six patients had factor V Leiden mutation (heterozygotes) which is statistically significant compared to control group (p = 0.01, OR 4.65) and 12 patients had mutation of MTHFR 677 (heterozygotes). None had prothrombin G20210A mutation.
Conclusion:
We found a statistically significant increase in the prevalence of factor V Leiden mutation (heterozygot) in Czech infertile women with severe OHSS. These findings suggest the increased risk of development of OHSS in these patients.
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