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Updated: Aug 11, 2026

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
Published on: August 28, 2012
[Genetic aspects of malignant epithelial ovarian tumours]
N Jancárková1, M Krkavcová, M Janashia
1Gynekologicko-porodnicki klinika 1. LF UK a VFN, Praha.
Objective:
To sum up the knowledge about genetic aspects of ovarian cancer.
Type Of Study:
Review article.
Setting:
Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University Prague and General Teaching Hospital Prague, Prague.
Methods:
Compilation of data from scientific literature.
Conclusions:
Ovarian cancer represents the most lethal malignancy among gynecological tumours. Etiology is still largely unknown. Multistep process, with accumulation of genetic alterations concerning factors with key role in cell regulation - oncogenes, tumor-supressor genes and mismatch-repair genes is supposed. Cytogenetic and molecular-genetic characteristics, in correlation with other molecular-biological parameters extend information of carcinogenesis. The final aim is to create a predictive model for clinical use.
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