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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Plasma matrix metalloproteinase-3 level is an independent prognostic factor in stable coronary artery disease

T C Wu1, H B Leu, W T Lin

  • 1National Yang-Ming University School of Medicine, Taipei, Taiwan, R.O.C.

European Journal of Clinical Investigation
|September 1, 2005
PubMed

Insights

Matrix metalloproteinases (MMPs) are elevated in coronary artery disease (CAD) patients. Plasma MMP-3 levels independently predict future cardiovascular events in stable CAD, aiding risk stratification.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Atherosclerosis Research

Background:

  • Matrix metalloproteinases (MMPs) play a role in atherosclerosis progression and clinical events.
  • Assessing the prognostic value of plasma MMPs in stable coronary artery disease (CAD) is crucial.

Purpose of the Study:

  • To evaluate the prognostic significance of various plasma MMPs in patients with stable CAD.
  • To determine if MMP levels can predict future cardiovascular events in this population.

Main Methods:

  • 165 nondiabetic patients with significant CAD or cardiac syndrome X and 17 normal subjects were analyzed.
  • Plasma levels of MMP-2, MMP-3, MMP-9, and high-sensitivity C-reactive protein (hsCRP) were measured.
  • CAD patients were prospectively followed for major cardiovascular events over 6 months.

Main Results:

  • CAD patients exhibited significantly higher plasma MMP levels (MMP-2, MMP-3, MMP-9) compared to controls.
  • Increased MMP-3 levels, along with diseased vessels and hsCRP, were associated with cardiovascular events.
  • Plasma MMP-3 level emerged as an independent predictor of adverse cardiovascular events in CAD patients.

Conclusions:

  • Plasma MMP levels are elevated in patients with CAD.
  • MMP-3 is a significant independent prognostic marker for cardiovascular events in stable CAD.
  • MMP-3 may be valuable for risk stratification and clinical management of stable CAD patients.
Abstract

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