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Measles, mumps, rubella antibody surveillance: pilot study in Grampian, Scotland
1Department of Public Health Medicine, Grampian Health Board, Aberdeen.
Abstract:
The prevalence of measles, mumps and rubella antibodies for ages over six months was obtained using a stratified random sample of stored sera submitted in 1988 prior to the implementation of MMR vaccine. Besides reflecting the different vaccination policies for the three viruses the results showed that males display earlier sero-conversion for all three infections and a higher proportion of older males are susceptible. Two-thirds of children aged 6-15 months had antibodies to measles, the majority of which were apparently vaccine induced. However, the possibility that a few children contract natural measles before the recommended age for MMR vaccine cannot be ruled out. A system of continuous sero-surveillance to monitor the effect of MMR vaccine is suggested.
Insights
Pre-MMR vaccine data revealed males had earlier sero-conversion for measles, mumps, and rubella, with older males showing higher susceptibility. Measles antibodies were common in infants, likely vaccine-induced, but natural infection before vaccination is possible.
Area of Science:
- Immunology
- Epidemiology
- Public Health
Background:
- Measles, mumps, and rubella (MMR) are significant viral infections.
- Understanding pre-vaccination antibody prevalence is crucial for public health strategies.
Purpose of the Study:
- To determine the seroprevalence of measles, mumps, and rubella antibodies in individuals over six months old before MMR vaccine implementation.
- To analyze seroconversion patterns and identify susceptible populations.
Main Methods:
- Stratified random sampling of stored sera from 1988.
- Serological testing for measles, mumps, and rubella antibodies.
Main Results:
- Males exhibited earlier seroconversion for all three infections compared to females.
- Older males demonstrated a higher proportion of susceptibility.
- Two-thirds of children aged 6-15 months possessed measles antibodies, predominantly vaccine-induced.
- The potential for natural measles infection before the recommended MMR vaccination age was noted.
Conclusions:
- Pre-MMR vaccine serosurveillance indicated distinct patterns of viral antibody prevalence and male susceptibility.
- Continuous serosurveillance is recommended to effectively monitor the impact of the MMR vaccine program.