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Updated: Aug 16, 2026
Routine Screening Method for Microparticles in Platelet Transfusions
Published on: January 31, 2018
Elevated circulating platelet-derived microparticles in patients with active inflammatory bowel disease
Akira Andoh1, Tomoyuki Tsujikawa, Kazunori Hata
1Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, Japan.
Objectives:
Platelet-derived microparticles (PDMPs) are active molecules involved in the hemostatic and inflammatory responses. To evaluate the changes in the platelet function in patients with inflammatory bowel disease (IBD), we measured circulating PDMP levels.
Methods:
Twenty-five healthy controls, 44 patients with ulcerative colitis (UC), and 43 patients with Crohn's Disease (CD) were studied. The PDMP and soluble P-selectin (sP-selectin) levels were measured by enzyme-linked immunosorbent assay (ELISA).
Results:
In the healthy controls, the PDMP levels were 17.2 +/- 6.2 U/mL. Significant differences were not observed between the healthy controls and inactive UC patients (20.8 +/- 9.5 U/mL, n = 25) or between the healthy controls and inactive CD patients (17.6 +/- 7.8 U/mL, n = 24). In contrast, the PDMP levels were significantly higher in both active UC (49.2 +/- 33.6 U/mL, n = 19) and active CD (48.6 +/- 42.8 U/mL, n = 19) patients than in the healthy controls. A significant correlation was found between the PDMP levels and the clinical activity indexes (CAI) of UC patients (r = 0.65, p < 0.01, n = 44), and between the PDMP levels and Crohn's disease activity indexes (CDAI) (r = 0.72, p < 0.01, n = 43). Elevated PDMP levels in active patients were significantly reduced after remission. A significant correlation was observed between the PDMP levels and the sP-selectin levels (r = 0.60, p < 0.01, n = 122).
Conclusion:
Elevated circulating PDMPs in active IBD patients suggest a role for platelets in the pathogenesis of IBD.
Insights
Platelet-derived microparticles (PDMPs) are elevated in active inflammatory bowel disease (IBD). These levels correlate with disease activity and decrease upon remission, suggesting platelets play a role in IBD.
Area of Science:
- Immunology
- Gastroenterology
- Hematology
Background:
- Platelet-derived microparticles (PDMPs) are bioactive molecules implicated in hemostasis and inflammation.
- Understanding platelet function alterations is crucial for inflammatory bowel disease (IBD) research.
Purpose of the Study:
- To investigate circulating PDMP levels in patients with ulcerative colitis (UC) and Crohn's disease (CD).
- To evaluate the correlation between PDMP levels and IBD disease activity.
Main Methods:
- Enzyme-linked immunosorbent assay (ELISA) was used to measure PDMP and soluble P-selectin (sP-selectin) levels.
- Study included 25 healthy controls, 44 UC patients, and 43 CD patients.
Main Results:
- PDMP levels were significantly higher in active UC and CD patients compared to healthy controls.
- PDMP levels correlated significantly with clinical activity indexes in both UC and CD.
- Elevated PDMP levels decreased significantly after achieving remission and correlated with sP-selectin levels.
Conclusions:
- Circulating PDMPs are elevated in active IBD patients.
- Platelets may contribute to the pathogenesis of inflammatory bowel disease.
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