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Related Experiment Video

Updated: Jul 11, 2026

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

Published on: October 20, 2015

Androgens induce CD-9 in human prostate tissue.

Y Chuan¹, S-T Pang, A Bergh

¹Department of Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. ake.pousette@medhs.ki.se

International Journal of Andrology

|September 1, 2005

Summary

CD-9 protein expression is regulated by androgens in prostate cancer cells. Its variable presence and localization in prostate tissues suggest a role in cancer development.

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Area of Science:

Urology
Molecular Biology
Oncology

Background:

Androgen sensitivity is crucial in prostate cancer progression.
The role of CD-9 protein in prostate cancer malignancy is not well understood.

Purpose of the Study:

To investigate the androgen regulation of CD-9 protein.
To analyze the correlation between CD-9 expression and prostate cancer malignancy.

Main Methods:

Microarray analysis of LNCaP and LNCaP-r cell lines.
Western blot, RT-PCR, and immunohistochemistry on cell lines and 88 human prostate cancer tissues.
Analysis of CD-9 expression in response to synthetic androgen R1881 and in different Gleason grades.

Main Results:

CD-9 expression was induced by R1881 in LNCaP cells.
CD-9 was localized in luminal and basal epithelial cells of non-malignant prostate tissue.
CD-9 staining intensity varied in tumor areas and was not related to Gleason grade; it was absent in tissues from patients under androgen ablation therapy.

Conclusions:

CD-9 is an androgen-regulated protein present in human prostate specimens.
Variable CD-9 expression and localization suggest a potential role in prostate cancer development and progression.