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Related Experiment Videos

Androgens induce CD-9 in human prostate tissue.

Y Chuan1, S-T Pang, A Bergh

  • 1Department of Molecular Medicine, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden. ake.pousette@medhs.ki.se

International Journal of Andrology
|September 1, 2005
PubMed
Summary
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CD-9 protein expression is regulated by androgens in prostate cancer cells. Its variable presence and localization in prostate tissues suggest a role in cancer development.

Area of Science:

  • Urology
  • Molecular Biology
  • Oncology

Background:

  • Androgen sensitivity is crucial in prostate cancer progression.
  • The role of CD-9 protein in prostate cancer malignancy is not well understood.

Purpose of the Study:

  • To investigate the androgen regulation of CD-9 protein.
  • To analyze the correlation between CD-9 expression and prostate cancer malignancy.

Main Methods:

  • Microarray analysis of LNCaP and LNCaP-r cell lines.
  • Western blot, RT-PCR, and immunohistochemistry on cell lines and 88 human prostate cancer tissues.
  • Analysis of CD-9 expression in response to synthetic androgen R1881 and in different Gleason grades.

Main Results:

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  • CD-9 expression was induced by R1881 in LNCaP cells.
  • CD-9 was localized in luminal and basal epithelial cells of non-malignant prostate tissue.
  • CD-9 staining intensity varied in tumor areas and was not related to Gleason grade; it was absent in tissues from patients under androgen ablation therapy.

    • Conclusions:

    • CD-9 is an androgen-regulated protein present in human prostate specimens.
    • Variable CD-9 expression and localization suggest a potential role in prostate cancer development and progression.