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Witkop tooth and nail syndrome: a case report
S Devadas1, B Varma, J Mungara
1Department of Paediatric and Preventive Dentistry, Ragas Dental College and Hospital, Chennai, India. drsheeba_das@hotmail.com
Abstract:
Witkop tooth and nail syndrome is an autosomal dominant ectodermal dysplasia characterized by hypodontia and nail dysplasia. Mutations in MSX-1 have been identified as being involved in the syndrome. Mandibular incisors, secondary molars and maxillary canines are the most frequently missing teeth. Tooth shape may vary, and conical and narrow crowns are common. Nail dysplasia affects finger- and toenails, and is often more severe in childhood. Nails may be spoon-shaped, rigid, slow-growing and easily broken. The clinical and radiographic features of a mother and child presenting with this rare condition are described.
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