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Anticancer activity of grape and grape skin extracts alone and combined with green tea infusions

Dorothy M Morré1, D James Morré

  • 1Department of Foods and Nutrition, Purdue University, 700 W. State Street, West Lafayette, IN 47907-2059, USA. morredm@cfs.purdue.edu

Cancer Letters
|September 1, 2005
PubMed

Insights

Grape extracts, particularly from skins and pomace, effectively inhibit cancer cell growth and a specific enzyme (tNOX). They also show synergistic effects with green tea extracts for enhanced anti-cancer activity.

Area of Science:

  • Oncology
  • Biochemistry
  • Pharmacology

Background:

  • Cancer cell growth is often associated with specific enzymes like cell surface NADH oxidase (tNOX).
  • Natural compounds from fruits and beverages are being investigated for their potential anti-cancer properties.

Purpose of the Study:

  • To evaluate the efficacy of grapes and grape extracts in inhibiting tNOX activity and cancer cell growth.
  • To explore synergistic interactions between grape extracts and green tea extracts.

Main Methods:

  • Assessing inhibition of tNOX activity in HeLa cells using grape extracts.
  • Evaluating the impact of grape extracts on HeLa and 4T1 cancer cell growth in vitro and in vivo.
  • Investigating synergistic effects with decaffeinated green tea extracts.

Main Results:

  • Grape extracts, especially from skins and pomace, demonstrated significant inhibition of tNOX activity and cancer cell growth.
  • Grape extracts exhibited synergistic effects with decaffeinated green tea extracts, enhancing anti-cancer activity.
  • Combined intratumoral injections of green tea extract and grape pomace extract were effective in inhibiting tumor growth in mice.

Conclusions:

  • Grape extracts possess potent anti-cancer properties targeting tNOX and cell proliferation.
  • Synergistic combinations of grape and green tea extracts offer a promising strategy for cancer therapy.

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