Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IL-6: from laboratory to bedside.

Tadamitsu Kishimoto1

  • 1Laboratory of Immune Regulation, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan. kishimot@imed3.med.osaka-u.ac.jp

Clinical Reviews in Allergy & Immunology
|September 1, 2005
PubMed
Summary

Researchers discovered B-cell stimulatory factor-2 (BSF-2), later identified as interleukin-6 (IL-6). This discovery paved the way for understanding IL-6

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Threonine phosphorylation of STAT1 safeguards gut epithelial integrity and restricts interferon-mediated cytotoxicity.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Threonine Phosphorylation and the Yin and Yang of STAT1: Phosphorylation-Dependent Spectrum of STAT1 Functionality in Inflammatory Contexts.

Cells·2024
Same author

Immunology and targeted therapy in Castleman disease.

Expert review of clinical immunology·2024
Same author

Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

IL-6/gp130 signaling in CD4<sup>+</sup> T cells drives the pathogenesis of pulmonary hypertension.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.

Proceedings of the National Academy of Sciences of the United States of America·2024

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • T-cells play a crucial role in antibody production.
  • The need for molecules released by T-cells to stimulate B-cells was hypothesized.
  • Early research in the late 1960s indicated T-cell involvement in B-cell activation.

Purpose of the Study:

  • To identify and characterize molecules released by T-cells that stimulate B-cell proliferation and differentiation.
  • To understand the molecular basis of B-cell activation and immunoglobulin production.
  • To investigate the potential therapeutic applications of understanding B-cell stimulating factors.

Main Methods:

  • Analysis of T-cell culture supernatants for B-cell stimulating activities.
  • Cloning of complementary DNA (cDNA) encoding the B-cell stimulatory factor.
  • Independent cloning and characterization of related proteins (interferon-beta2, 26-kDa protein, hybridoma/plasmacytoma growth factor, hepatocyte-stimulating factor) for molecular identity confirmation.

Main Results:

  • Discovery of a factor in T-cell supernatants inducing B-cell proliferation and differentiation, named B-cell stimulatory factor (BSF)-2.
  • Cloning of human BSF-2 cDNA in 1986.
  • Identification of BSF-2 as identical to interferon-beta2, 26-kDa protein, hybridoma/plasmacytoma growth factor, and hepatocyte-stimulating factor, leading to its unification as interleukin-6 (IL-6).

Conclusions:

  • Interleukin-6 (IL-6) is a pleiotropic cytokine with diverse biological activities.
  • IL-6 plays a significant role in immune responses and is implicated in various diseases, including rheumatoid arthritis and Castleman's disease.
  • Understanding the IL-6 system provides a basis for developing targeted therapies for chronic inflammatory diseases by blocking IL-6 action.

Related Experiment Videos