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Updated: Aug 16, 2026

Establishment of an Embryo Implantation Model In Vitro
Published on: June 21, 2024
Cytokines and implantation
Gérard Chaouat1, Nathalie Ledée-Bataille, Karen Bonnet Chea
1Equipe cytokines et relation materno foetale U131 INSERM, Hôpital Antoine Béclère (AP-HP), Clamart, France.
Abstract:
This review introduces the field of cytokines and implantation and then recalls the specialized role of the uterus and the notion of the 'implantation window'. The role of inflammatory and angiogenic cytokines is presented, as well as the involvement of cytokines such as -interferons in corpus luteum maintenance in non-chorionic gonadotrophin-producing species. -Interferons are reviewed, before dealing with the more in depth analysis of cytokine networks in the pre- and peri-implantation uterus. The emerging involvement of cytokines in controlling uterine vascularization angiogenesis is reviewed, with emphasis on NK activating factors.
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