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Updated: Aug 16, 2026

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay
10:28

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay

Published on: January 8, 2012

Trophoblast invasion and placentation: molecular mechanisms and regulation

Frédéric van den Brûle1, Sarah Berndt, Nadine Simon

  • 1Laboratory of Tumor Biology and Development, Pathology B23, CHU Liège, Liège, Belgium.

Chemical Immunology and Allergy
|September 1, 2005
PubMed

Trophoblast invasion is a key process during human placentation. This event constitutes the basis of the conversion of the uterine spiral arteries, a process which allows an adequate vascular connection between the intervillous space and the maternal blood flow. Trophoblast invasion is transient, with stringent spatial and temporal control. Preeclampsia, a leading cause of maternal and fetal mortality and morbidity, is associated with decreased, shallow trophoblastic invasion. In this article, we review the molecular mechanisms of trophoblast invasion, and its mechanisms of regulation. Insights into the etiopathogenesis of preeclampsia will also be detailed.

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