Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The complement system at the fetomaternal interface.

Roberta Bulla1, Fleur Bossi, Fabio Fischetti

  • 1Department of Physiology and Pathology, University of Trieste, Trieste, Italy.

Chemical Immunology and Allergy
|September 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Gut-Vagina Axis.

Microorganisms·2026
Same author

Correction: Anti-β2GPI IgG display a broad reactivity against different β2GPI domains beyond domain 1: results from the APS ACTION and multi-center Italian cohorts.

Frontiers in immunology·2026
Same author

Pediatric endoscopic pilonidal sinus treatment (PEPSiT) as standard of care results over 10 years' experience in 507 patients.

Scientific reports·2026
Same author

Anti-β2GPI IgG display a broad reactivity against different β2GPI domains beyond domain 1: results from the APS ACTION and multi-center Italian cohorts.

Frontiers in immunology·2026
Same author

Learning Curve of Docking Time in Robot-Assisted Radical Prostatectomy with the Hugo RAS System: How Many Procedures to Achieve Efficiency?

Journal of clinical medicine·2026
Same author

On the correlation between training modalities and recovery stages in poststroke robotic rehabilitation of the upper limb: a systematic review.

Journal of neuroengineering and rehabilitation·2026
Same journal

Educational programmes in food allergy.

Chemical immunology and allergy·2015
Same journal

Prevention of food allergy.

Chemical immunology and allergy·2015
Same journal

The effects of food allergy on quality of life.

Chemical immunology and allergy·2015
Same journal

Worldwide food allergy labeling and detection of allergens in processed foods.

Chemical immunology and allergy·2015
Same journal

Food allergy: psychosocial impact and public policy implications.

Chemical immunology and allergy·2015
Same journal

Nutritional aspects and diets in food allergy.

Chemical immunology and allergy·2015
See all related articles

The placenta uses complement regulators to protect the fetus from maternal immune attack during pregnancy. However, excessive complement activation in pathological pregnancies can overwhelm these protective mechanisms.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Maternal-Fetal Medicine

Background:

  • The placenta facilitates fetal-maternal tolerance despite fetal cells expressing paternal antigens.
  • Maternal immune components, including complement, constantly interact with placental tissues.

Purpose of the Study:

  • To review the role of the complement system in placental physiology and pathology.
  • To explore protective mechanisms against complement-mediated damage at the placental level.

Main Methods:

  • Review of existing literature on placental complement system.
  • Analysis of complement component deposition in physiological and pathological pregnancies.

Main Results:

  • Complement components are present in placental tissue, originating from maternal blood and local production.

Related Experiment Videos

  • Complement deposition occurs in both normal and pathological pregnancies, but excessive deposition is linked to adverse outcomes.
  • Villous trophoblast expresses complement regulators that protect the fetus.

    • Conclusions:

    • The complement system plays a dual role in pregnancy, with regulatory mechanisms protecting the fetus.
    • Pathological conditions can lead to excessive complement activation, potentially harming the fetus despite regulatory defenses.