Related Experiment Video
Updated: Aug 16, 2026

Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation
Published on: November 3, 2018
Clinical course of myelodysplastic syndromes
1Department of Hematology, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.
Abstract:
The myelodysplastic syndromes are a heterogeneous group of disease states ranging from relatively benign to aggressive forms. It is now possible to specify factors with prognostic value. Poor-prognosis factors that can easily be assessed are (1) bone marrow blasts exceeding 5% of the nucleated cells, (2) the presence of blast cells in the peripheral blood, (3) pancytopenia, and (4) a high Bournemouth, FAB, Düsseldorf, or Spanish score. Further important poor-prognosis features are (5) the presence of karyotypic abnormalities, (6) the finding of ALIP, and (7) a leukemic pattern of in vitro progenitor cell growth. The assessment of the value of therapeutic intervention either by treatment with hematopoietic growth factors or by chemotherapy will require the knowledge of the distribution of these features.
Related Concept Videos
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Differentiation of Common Myeloid Progenitor Cells
Cellular Adaptation IV: Dysplasia and Metaplasia
Multiple Sclerosis l: Introduction

