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Sleep disorders in the medically ill patient
1National Jewish Center for Immunology and Respiratory Medicine, University of Colorado School of Medicine, Denver.
The Journal of Clinical Psychiatry
|June 1, 1992
Summary
Medical evaluation is key for disturbed sleep. This review covers metabolic, neurologic, and medication factors, including sleep apnea, and pharmacokinetic considerations for treatment.
Area of Science:
- Sleep Medicine
- Neurology
- Pharmacology
Background:
- Disturbed sleep is a common complaint requiring thorough medical evaluation.
- Identifying underlying metabolic, neurologic, or medication-related factors is crucial.
Purpose of the Study:
- To review medical and neurologic conditions affecting sleep.
- To discuss commonly implicated medications and their impact on sleep.
- To highlight pharmacokinetic considerations in treating sleep disturbances in medical patients.
Main Methods:
- Literature review of medical and neurologic conditions impacting sleep.
- Analysis of medications known to cause sleep disturbances.
- Discussion of pharmacokinetic principles relevant to sleep disorder pharmacotherapy.
Main Results:
- Various medical and neurologic conditions can negatively affect sleep quality.
- Numerous medications are associated with the development or exacerbation of sleep problems.
- Sleep apnea syndromes are a significant cause of disturbed sleep.
- Pharmacokinetic factors influence the choice and efficacy of sleep medications.
Conclusions:
- A comprehensive medical evaluation is essential for patients with disturbed sleep.
- Understanding contributing factors, including medications and specific conditions like sleep apnea, guides effective treatment.
- Tailoring pharmacotherapy based on pharmacokinetic profiles is vital for managing sleep disturbances in medical patients.