Synthesis and anti-rhinovirus properties of fluoro-substituted flavonoids
Cinzia Conti1, Paola Mastromarino, Paola Goldoni
1Dipartimento di Scienze di Sanitá Pubblica, Sezione di Microbiologia, Universitá La Sapienza di Roma, Roma, Italy.
Abstract:
Fluoro-substituted flavones and 2-styrylchromones, related to natural and synthetic flavonoids previously described, were prepared, characterized and tested for anti-rhinovirus activity. Structural elucidation of the new compounds was performed by IR, NMR spectra and X-ray crystal structure analysis for 6-fluoro-3-hydroxy-2-styrylchromone. The antiviral potency was evaluated by a plaque reduction assay in HeLa cell cultures infected with rhinoviruses 1B and 14, selected as representative serotypes for viral groups B and A of human rhinoviruses, respectively. In comparison with results previously obtained, the introduction of the fluorine atom seems to exert a positive influence on the activity against serotype 14 while counteracting the effect against serotype 1B.
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