Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chemotherapy dosing with elevated liver function test results in acute leukemia.

Terrance B Comeau1, Debra L Phillips

  • 1Bone Marrow and Stem Cell Transplantation Program, Division of Hematology and Medical Oncology, School of Medicine, The University of North Carolina, Chapel Hill, NC, USA.

The Annals of Pharmacotherapy
|September 1, 2005
PubMed
Summary

Massive liver infiltration by acute lymphoblastic leukemia (ALL) can worsen liver function tests. Prompt diagnosis and tailored chemotherapy dosing are crucial for managing ALL patients with liver dysfunction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioral numbness associated with intravenous pentamidine administration.

The Annals of pharmacotherapyยท2006
See all related articles

Area of Science:

  • Hematology
  • Oncology
  • Hepatology

Background:

  • Acute lymphoblastic leukemia (ALL) can infiltrate various organs, including the liver.
  • Liver dysfunction in ALL patients may complicate chemotherapy administration.
  • Monitoring liver function tests (LFTs) is essential during leukemia treatment.

Observation:

  • A 36-year-old male with pre-B cell ALL presented with worsening LFTs shortly after diagnosis.
  • Transvenous liver biopsy revealed massive lymphoblast infiltration of the liver.
  • Chemotherapy dosing was a concern due to the patient's liver dysfunction.

Findings:

  • A short course of prednisone was initiated to assess LFT response.
  • Reversal of LFT abnormalities was observed with prednisone treatment.

Related Experiment Videos

  • Full-dose induction chemotherapy was successfully administered after demonstrating LFT improvement.

    • Implications:

    • Identifying the cause of elevated LFTs in acute leukemia is critical.
    • Liver infiltration by ALL necessitates careful treatment planning.
    • Accurate assessment of liver involvement impacts chemotherapy decisions and patient prognosis.