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Updated: Aug 16, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Pulmonary infiltrates with eosinophilia induced by nimesulide in an asthmatic patient
Diahn-Warng Perng1, Hsuan-Tsung Su, Chih-Wei Tseng
1Department of Chest Medicine, Taipei Veterans General Hospital, #201 Section 2 Shih-Pai Road, Taipei 11217, Taiwan, ROC. dwperng@vghtpe.gov.tw
Abstract:
We report a case of pulmonary infiltrates with eosinophilia (PIE) induced by nimesulide in an asthmatic patient on regular inhaled corticosteroid treatment. A high level of eosinophils in induced sputum was detected. No evidence of bacterial or fungal infection was observed. The patient responded rapidly to corticosteroid treatment. Rechallenge with nimesulide induced blood and sputum eosinophilia, confirming our diagnosis. Nimesulide, though it is a relatively safe drug to use in aspirin-sensitive asthmatics, may (like other nonsteroidal anti-inflammatory drugs) cause PIE in asthmatic patients and thus should be used cautiously.
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