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Interleukin 1 beta polymorphism (-511) and risk of stroke due to small vessel disease

Tomasz Dziedzic¹, Agnieszka Slowik, Joanna Pera

¹Department of Neurology, Collegium Medicum, Jagiellonian University, Krakow, Poland. Dziedzic@cm-uj.krakow.pl

Cerebrovascular Diseases (Basel, Switzerland)

|September 1, 2005

Abstract

Background:

Interleukin 1 (IL-1) is a proinflammatory cytokine involved in atherogenesis and thrombosis. The aim of this study was to investigate the association between the IL-1beta gene polymorphism (-511) and the risk of large vessel disease (LVD) stroke, small vessel disease (SVD) stroke and cardioembolic (CE) stroke.

Methods:

We genotyped 115 patients with LVD stroke and 194 matched controls, 122 patients with SVD stroke and 227 controls and 221 patients with CE stroke and 219 controls. The IL-1beta polymorphism was analyzed by a polymerase chain reaction followed by a restriction enzyme digestion.

Results:

The allele T distribution did not change significantly between patients with LVD stroke and their controls nor between patients with CE stroke and their controls. The frequency of the T allele was higher in patients with SVD stroke than in the control group (37.7 vs. 30.4%, p = 0.05). After adjustment for vascular risk factor, the TT genotype was an independent risk factor for SVD stroke (OR: 2.40, 95% CI: 1.17-4.94).

Conclusions:

The TT genotype of the IL-1beta gene may be associated with an increased risk of SVD stroke.

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