Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Th1/Th2 paradigm in ocular allergy.

Michael E Stern1, Karyn F Siemasko, Jerry Y Niederkorn

  • 1Department of Biological Sciences, Allergan, Inc., Irvine, California, USA. Stern_Michael@allergan.com

Current Opinion in Allergy and Clinical Immunology
|September 1, 2005
PubMed
Summary

The Th1/Th2 paradigm is challenged in ocular allergy. Understanding T helper cell mechanisms, particularly IFN-gamma

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world evaluation of belumosudil for chronic ocular graft-versus-host-disease: Efficacy and outcomes.

Bone marrow transplantation·2026
Same author

The effect of posttransplant cyclophosphamide on ocular graft-versus-host disease.

Bone marrow transplantation·2025
Same author

Dessicating stress triggers and exacerbates experimental ocular Graft-versus-host-disease.

The ocular surface·2025
Same author

Long-Term Trajectories of Older Adults Served by an Emergency Department/Hospital-Based Elder Mistreatment Response Program.

Journal of the American Geriatrics Society·2025
Same author

Emergency department and hospital-based programs responding to elder mistreatment: developing consensus about an idea whose time has come.

Journal of elder abuse & neglect·2024
Same author

Elder abuse geriatrics: describing an important new medical specialist.

Journal of elder abuse & neglect·2024

Area of Science:

  • Immunology
  • Ophthalmology
  • Allergy Research

Background:

  • The traditional Th1/Th2 paradigm for disease mediation is increasingly challenged in ocular conditions.
  • Ocular allergy involves complex immune responses that require a deeper mechanistic understanding.

Purpose of the Study:

  • To emphasize the critical need for understanding T helper 1 (Th1) and T helper 2 (Th2) cell mechanisms in ocular allergy pathology.
  • To explore the role of specific cytokines and cellular interactions in chronic allergic conjunctivitis.

Main Methods:

  • Utilized a multi-hit short ragweed antigen challenge model in BALB/c wild type mice.
  • Investigated IFN-gamma knockout mice to assess the impact of IFN-gamma deficiency on allergic conjunctivitis.
  • Evaluated conjunctival cellular infiltrate and adhesion molecule expression (VCAM-1).

Main Results:

  • Th2-prone mice developed chronic conjunctival inflammation following repeated antigen challenge.
  • IFN-gamma knockout mice exhibited reduced conjunctival cellular infiltration in the allergic model.
  • Vascular cell adhesion molecule-1 (VCAM-1) expression was diminished in IFN-gamma knockout mice.

Conclusions:

  • Current research questions the strict Th1/Th2 classification in ocular allergy.
  • Further investigation into Th1 and Th2 cytokine interactions is crucial for understanding ocular inflammatory diseases.
  • IFN-gamma plays a significant role as an endothelial gatekeeper in Th2-mediated allergic conjunctivitis.

Related Experiment Videos