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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Highly-functionalised difluorinated cyclohexane polyols via the Diels-Alder reaction: regiochemical control via the

Patrick J Crowley1, John Fawcett, Gerry A Griffith

  • 1Syngenta Ltd., Jealott's Hill International Research Centre, Bracknell, Berkshire, UK RG42 6EY.

Organic & Biomolecular Chemistry
|September 1, 2005
PubMed

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Characteristics of the diene
Conformation
The simplest example of a diene is 1,3-butadiene, an acyclic conjugated π system. At room temperature, the molecule exists as a mixture of s-cis and s-trans conformers by virtue of rotation around the carbon–carbon single bond. Although the s-trans isomer is more stable, the...