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Related Experiment Videos

Olfactory ensheathing cell tumor: a case report.

Muneyoshi Yasuda1, Osamu Higuchi, Shingo Takano

  • 1Department of Neurosurgery, Hitachi Ltd., Mito General Hospital, and Department of Neurosurgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan. ymune@par.odn.ne.jp

Journal of Neuro-Oncology
|September 1, 2005
PubMed
Summary

Olfactory ensheathing cell (OEC) tumors can mimic schwannomas on the anterior skull base. Immunohistochemistry, particularly CD57 (Leu7) staining, is crucial for differentiating these rare tumors.

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Area of Science:

  • Neuro-oncology
  • Surgical Pathology
  • Skull Base Tumors

Background:

  • Schwannomas are common nerve sheath tumors, but their occurrence on the anterior skull base is rare.
  • Olfactory ensheathing cells (OECs) share similarities with Schwann cells but have distinct immunohistochemical profiles.

Observation:

  • A 31-year-old woman presented with a convulsion and an anterior skull base tumor.
  • Radiological and histological examination revealed a heterogeneously enhanced, spindle-shaped cell tumor.
  • Initial suspicion of schwannoma was revised based on S-100 positivity and negativity for EMA and CD57 (Leu7).

Findings:

  • The tumor exhibited immunohistochemical characteristics consistent with an olfactory ensheathing cell (OEC) tumor.
  • OEC tumors are differentiated from schwannomas by their CD57 (Leu7) negativity.

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  • This case suggests OECs as a potential origin for some anterior skull base tumors previously diagnosed as schwannomas.

    • Implications:

    • This case expands the differential diagnosis for anterior skull base tumors.
    • It highlights the importance of specific immunohistochemical markers in distinguishing OEC tumors from schwannomas.
    • Further research into the pathogenesis of OEC tumors is warranted.