Related Experiment Video
Updated: Aug 16, 2026

Cultivation of Mammalian Cells Using a Single-use Pneumatic Bioreactor System
Published on: October 10, 2014
A novel oscillating bioreactor BelloCell: implications for insect cell culture and recombinant protein production
Jen-Te Lu1, Yao-Chi Chung, Zun-Ren Chan
1Department of Chemical Engineering, National Tsing Hua University, 300, Hsinchu, Taiwan.
Abstract:
BelloCell is a novel packed bed bioreactor that allows alternating nutrient and gas transfer to a culture. Spodoptera frugiperda Sf-9 grown in the BelloCell (300 ml culture) reached 1.3-1.5x10(7) cells ml-1 in 7-8 days and the total baculovirus-expressed protein yield was 2.3-times that in a stirred tank bioreactor (600 ml culture). The superior cell and protein yields underline the potential of BelloCell for cell culture and recombinant protein production.
More Related Videos
Related Concept Videos
Bioreactor Controls-II
Bioreactor Design and Operational System
Upstream Processing
Bioreactor Controls-III

