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[Rosacea. Clinical features, pathogenesis and therapy].

P Lehmann1

  • 1Klinik für Dermatologie, Allergologie und Umweltmedizin, HELIOS-Klinikum Wuppertal, Universität Witten-Herdecke, Wuppertal. plehmann@wuppertal.helios-kliniken.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|September 1, 2005
PubMed
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Rosacea is a common facial skin condition affecting middle-aged individuals, primarily those with lighter skin types. Treatment ranges from topical medications for mild cases to systemic therapies and surgery for severe rosacea.

Area of Science:

  • Dermatology
  • Pathophysiology of skin diseases

Context:

  • Rosacea is a prevalent facial dermatosis impacting psychological and social well-being.
  • It predominantly affects middle-aged individuals with skin types I and II.
  • Clinical presentation includes flushing, erythemato-telangiectasies, papulopustules, and inflammatory nodules.

Purpose:

  • To provide an overview of rosacea, including its clinical manifestations, pathogenesis, and treatment options.
  • To differentiate between various subtypes and stages of rosacea.
  • To discuss therapeutic strategies for mild to severe forms of the condition.

Summary:

  • Pathogenesis involves dermal vessel and connective tissue destruction leading to chronic inflammation.
  • Mild rosacea is managed with topical agents like metronidazole, azelaic acid, antibiotics, and adapalene.

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  • Severe rosacea requires systemic treatments, including antibiotics and isotretinoin, with surgical intervention for rhinophyma.

    • Impact:

    • Effective management can mitigate the detrimental psychological and social effects of rosacea.
    • Understanding disease subtypes guides appropriate therapeutic choices.
    • Current treatments offer significant improvement for various rosacea presentations.