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Updated: Aug 16, 2026

Patient-derived Orthotopic Xenograft Models for Human Urothelial Cell Carcinoma and Colorectal Cancer Tumor Growth and Spontaneous Metastasis
Published on: May 12, 2019
Upper urinary tract metastases from adenocarcinoma of the colon
C T Sofocleous1, K T Brown, S Savage
1Memorial Sloan Kettering Cancer Center, Image Guided Therapies and Interventional Radiology, 1275 York Avenue, New York, NY 10021, USA. constant@pol.net
Abstract:
An unusual presentation of colorectal metastasis to the upper urinary tract is reported. The metastasis manifested as a filling defect seen during antegrade pyelography. Cytologic evaluation of aspirated material demonstrated metastatic colonic adenocarcinoma. A dilated collecting system may be caused by intraluminal material including tumor and blood clots. Whenever fixed filling defects are encountered, urine cytology should be sent even in the absence of renal parenchymal involvement by tumor. The cytological evaluation may allow for prompt diagnosis and treatment.
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