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[Chromosome STR genetic markers in paternity identification]
1Department of Forensic Medicine, Xiangya School of Medicine, Central South University, Changsha 410078, China. tzc9065@hotmail.com
Summary
Paternity identification using short tandem repeat (STR) genetic markers is effective. High W values and specific allelic gene patterns confirm relatedness in paternity testing.
Area of Science:
- Forensic genetics
- Human genetics
- Molecular biology
Context:
- Paternity testing relies on genetic markers to establish biological relationships.
- Short tandem repeat (STR) markers are widely used due to their high polymorphism and discriminatory power.
Purpose:
- To evaluate the efficacy of chromosome STR genetic markers for paternity identification.
- To establish criteria for confirming paternity based on STR analysis.
Summary:
- Paternity testing was performed on 468 cases using STR Profiler plus and Cofiler kits.
- Exclusions were further investigated using HLA typing and the PowerPlex 16 system, including Y-STR, X-STR, and HLA sequencing when necessary.
- High paternity index (W) values (>0.95 or >0.9995) were observed in 408 and 350 cases, respectively, while unrelated individuals showed lower W values (<0.8 or <0.27).
- Statistical analysis revealed significant differences in entirely-same and entirely-different allelic genes between related and unrelated pairs.
Impact:
- STR genetic markers provide a reliable and effective method for paternity identification.
- Specific genetic profiles, such as fewer than 1 entirely-different allelic genes or more than 6 entirely-same allelic genes, strongly indicate a related pair.