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EEG frequency and cognitive dysfunction in patients with Parkinson's disease
Osman Sinanović1, Almasa Kapidzić, Larisa Kovacević
1Department of Neurology, University Clinical Center, School of Medicine, University of Tuzla.
Medicinski Arhiv
|September 2, 2005
Summary
Parkinson's disease patients with dementia show more frequent EEG slowing. This study found a positive correlation between EEG frequency and Mini Mental Status scores in Parkinson's patients.
Area of Science:
- Neurology
- Neurophysiology
Background:
- Parkinson's disease (PD) is associated with electroencephalogram (EEG) changes compared to healthy individuals.
- Generalized or localized slowing of EEG frequency is a commonly observed change in PD patients.
Purpose of the Study:
- To investigate the correlation between EEG frequency and Mini Mental Status (MMS) scores in Parkinson's disease patients.
- To compare EEG frequency patterns between PD patients with and without dementia.
Main Methods:
- Analysis of 32 Parkinson's disease patients (mean age 64.63 years, 75% male).
- Patients were categorized into two groups based on MMS scores: with dementia (MMS < 24) and without dementia (MMS ≥ 24).
- EEG frequency values were determined for both groups.
Main Results:
- A positive correlation (r = 0.46) was observed between EEG frequency and MMS scores.
- Patients with dementia (n=21) exhibited more frequent EEG slowing (diffuse 19.04%, localized 80.96%) compared to those without dementia (n=11) (diffuse 9.1%, localized 90.9%).
- Localized slowing was more prevalent than diffuse slowing in both groups, but particularly pronounced in the non-dementia group.
Conclusions:
- EEG slowing frequency is significantly more common in Parkinson's disease patients who have dementia.
- The findings suggest a link between cognitive decline, specifically dementia, and altered EEG frequency patterns in Parkinson's disease.