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Updated: Aug 16, 2026

Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
Published on: April 6, 2017
Structure and oxidation capacity of amino acid chloramine derivatives and their effects on platelet aggregation
M A Murina1, N A Chudina, D I Roshchupkin
1Research Institute of Physicochemical Medicine, Ministry of Health of Russia, Moscow. marina_murina@mail.ru
Abstract:
Comparison of antiaggregation capacity of N-chloramine acids with different position of the chloramine group in the molecule showed that in the most efficient compounds the distance between the chloramine and carboxyl groups was 3-5 carbon atoms. This feature of antiaggregation activity was not related to the difference in oxidation capacity of N-chloramine acids. It was hypothesized that the revealed structural dependence of antiaggregation activity of N-chloramine acids is determined by the structure of platelet membrane, in particular, the presence of a negatively charged group near the site of interaction between N-chloramine acids and platelet membrane.
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