Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sarcoidosis caused by interferon therapy.

Göhkan Celik1, Elif Sen, A Fusun Ulger

  • 1Department of Pulmonary Diseases, Ankara University School of Medicine, Ankara, Turkey. celik@medicine.ankara.edu.tr

Respirology (Carlton, Vic.)
|September 2, 2005
PubMed
Summary

Interferon alpha (IFN-alpha) therapy for hepatitis C can trigger sarcoidosis. Patients require monitoring for this autoimmune condition during and after treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of Latent Tuberculosis Infection Risk in Liver Transplant Recipients.

Journal of clinical medicine·2026
Same author

Validation and Reliability Assessment of the Test of Adherence to Inhalers (TAI) in Turkish Patients with Chronic Obstructive Pulmonary Disease (COPD).

Thoracic research and practice·2026
Same author

Reliability of Pulmonary Function Tests in Patients with Chronic Obstructive Pulmonary Disease.

International journal of chronic obstructive pulmonary disease·2026
Same author

Rare Neurosarcoidosis Involvements.

Respirology case reports·2026
Same author

Temporal Trends in the Use of Pulmonary Function Tests Before, During, and After the COVID-19 Pandemic: Experience from a University Hospital in Türkiye.

Thoracic research and practice·2026
Same author

Interstitial Pneumonia with Autoimmune Features from the Rheumatologists' Perspective; Single Center Experience.

Diagnostics (Basel, Switzerland)·2026

Area of Science:

  • Immunology
  • Hepatology
  • Dermatology

Background:

  • Interferon alpha (IFN-alpha) is an immunomodulator used to treat chronic viral hepatitis C.
  • IFN therapy is known to potentially induce or worsen sarcoidosis, an autoimmune condition.
  • While gastroenterology literature notes this association, it is infrequently reported elsewhere.

Observation:

  • A 47-year-old woman developed sarcoidosis following treatment with IFN and ribavirin for hepatitis C.
  • Her sarcoidosis presented with multi-organ involvement, including the liver, lungs, and skin.
  • The patient's condition improved spontaneously without requiring steroid therapy.

Findings:

  • The case highlights a potential link between IFN therapy and the onset of sarcoidosis.
  • Sarcoidosis can manifest with diverse organ involvement after viral hepatitis treatment.

Related Experiment Videos

  • Spontaneous remission of IFN-induced sarcoidosis is possible.

    • Implications:

    • Healthcare providers should vigilantly monitor patients for sarcoidosis during and after IFN therapy.
    • Increased awareness of this adverse effect is crucial for timely diagnosis and management.
    • Further research may elucidate the mechanisms underlying IFN-induced sarcoidosis.