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[MEF2 and myogenesis].

Zhen-long Cheng1, Da-hai Zhu, Zhi-qian Zhang

  • 1Molecular and Cellular Developmental Biology Laboratory, Harbin Institute of Technology, Harbin 150001,China.

Yi Chuan = Hereditas
|September 2, 2005
PubMed
Summary
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The myocyte enhancer factor 2 (MEF2) network is crucial for skeletal muscle development. MEF2 interacts with MyoD factors to regulate muscle gene transcription and growth.

Area of Science:

  • Molecular Biology
  • Genetics
  • Developmental Biology

Context:

  • Skeletal muscle formation and growth are complex processes.
  • A core regulatory network involving transcription factors controls myogenesis.

Purpose:

  • To review the molecular mechanisms of MEF2 interactions in skeletal muscle development.
  • To highlight the essential roles of MEF2 in myogenesis.

Summary:

  • Skeletal muscle development is governed by MyoD family (MRFs) and myocyte enhancer factor 2 (MEF2) transcription factors.
  • MEF2 interacts with MRFs to regulate muscle-specific gene expression during development.
  • This review details the molecular basis of these interactions and MEF2's role in muscle growth.

Impact:

Related Experiment Videos

  • Provides a comprehensive overview of MEF2's function in skeletal muscle.
  • Enhances understanding of the genetic control of myogenesis.
  • Serves as a resource for researchers in muscle biology and developmental genetics.