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Related Experiment Videos

No association between schizophrenia and polymorphisms in COMT in two large samples.

Hywel J Williams1, Beate Glaser, Nigel M Williams

  • 1Department of Psychological Medicine, Henry Wellcome Building for Biomedical Research, Cardiff University, Heath Park, Cardiff, CF14 4XN, UK.

The American Journal of Psychiatry
|September 2, 2005
PubMed
Summary

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This study found no evidence that a specific gene variant (COMT valine/methionine polymorphism) or haplotype increases schizophrenia risk in European populations. Genetic factors influencing schizophrenia susceptibility require further investigation.

Area of Science:

  • Genetics
  • Psychiatry
  • Neuroscience

Background:

  • The catechol O-methyltransferase (COMT) gene is implicated in dopamine metabolism, a neurotransmitter system dysregulated in schizophrenia.
  • Previous studies suggested a link between COMT gene polymorphisms and schizophrenia susceptibility, particularly in specific ethnic groups.

Purpose of the Study:

  • To investigate the association between a valine/methionine polymorphism in the COMT gene and schizophrenia risk.
  • To examine the role of a specific COMT haplotype in schizophrenia susceptibility among Ashkenazi Jewish and Irish populations.

Main Methods:

  • A comprehensive review of data from over 2,800 individuals, including nearly 1,200 diagnosed with schizophrenia.
  • Utilized case-control and family-based European association samples to assess genetic associations.

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Main Results:

  • No statistical support was found for the hypothesis that the COMT valine/methionine polymorphism influences schizophrenia susceptibility.
  • The study did not find evidence that a specific COMT haplotype increases schizophrenia risk in Ashkenazi Jewish and Irish subjects.

Conclusions:

  • The valine allele of the COMT gene does not appear to elevate schizophrenia susceptibility in European populations.
  • The examined COMT haplotype does not confer increased risk for schizophrenia in the studied ethnic groups.
  • While linkage disequilibrium patterns at COMT may vary across populations, the valine allele's role in schizophrenia susceptibility is not supported in Europeans.