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Published on: April 5, 2011
Tetanic crisis and antiepileptic drugs. A case report
Zygmunt Zdrojewicz1, Andrzej Dubiński, Aneta Jonek
1Department of Endocrinology & Diabetology, Wroclaw Medical University, Wroclaw, Poland.
Objective And Methods:
We presented a rare case of tetanic crisis in a 23-year old mentally retarded woman with epilepsy after treatment by oxcarbazepine, the new anticonvulsant agent. We reviewed laboratory, radiographic and medical examinations and recommend a proper treatment in such cases.
Results And Conclusion:
The laboratory tests revealed only severe hypocalcemia. We described the potential role of oxcarbazepine in the induction of activity of cytochrome P 450 system of hepar and increases of less active metabolism of vitamin D. Supplementation of vitamin D and calcium in patients taking antiepileptic drugs is in the same case crucial.
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