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Updated: Aug 16, 2026

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution
Published on: June 23, 2022
Do septins have a role in cancer?
1Centre for Cancer Research & Cell Biology, Queen's University Belfast, University Floor, Tower Block, Belfast City Hospital, Belfast BT9 7AB, UK.
Septins are proteins involved in cell division and structure. Altered septin gene expression is linked to cancer development, suggesting their role as cancer critical genes.
Area of Science:
- Molecular Biology
- Cell Biology
- Genetics
Background:
- Septins are conserved protein families with GTP-binding domains.
- They play crucial roles in cell division, membrane dynamics, and cytoskeletal organization.
- Human septins exhibit extensive alternative splicing and complex expression patterns.
Purpose of the Study:
- To review the fundamental properties of septins.
- To summarize evidence linking septin alterations to human neoplasia.
- To explore septins' potential role as cancer critical genes.
Main Methods:
- Literature review of septin biology and cancer associations.
- Analysis of gene expression patterns in human diseases.
- Evaluation of septin function in cellular processes relevant to cancer.
Main Results:
- Septins form hetero-oligomeric complexes and act as protein scaffolds.
- At least 13 human septin genes exist with significant alternative splicing.
- Altered septin expression profiles are observed in human neoplasia.
Conclusions:
- Septins are implicated in various cellular functions relevant to cancer.
- Changes in septin expression, not just mutations, may drive their role in neoplasia.
- Septins represent a potential class of cancer critical genes.
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