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The human orbitofrontal cortex: linking reward to hedonic experience.

Morten L Kringelbach1

  • 1University of Oxford, University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK. morten.kringelbach@physiol.ox.ac.uk

Nature Reviews. Neuroscience
|September 2, 2005
PubMed
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The orbitofrontal cortex, a key brain region, is central to linking rewards like food to hedonic experience. This study explores its neuroanatomy and proposes a new model for its role in human pleasure and reward processing.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Hedonic experience is fundamental to human behavior and consciousness.
  • The orbitofrontal cortex (OFC) is increasingly implicated in processing reward and pleasure.
  • Understanding the OFC's function is crucial for comprehending reward-based behaviors.

Purpose of the Study:

  • To describe the functional neuroanatomy of the human orbitofrontal cortex.
  • To propose an integrated model of OFC functions.
  • To elucidate the OFC's role in mediating hedonic experience.

Main Methods:

  • Review of recent neuroimaging studies.
  • Analysis of functional neuroanatomy.
  • Development of a theoretical model.

Related Experiment Videos

Main Results:

  • The orbitofrontal cortex is a strong candidate for linking rewards to hedonic experience.
  • The OFC is involved in sensory integration, representing affective value, and decision-making.
  • A novel integrated model of OFC function is proposed.

Conclusions:

  • The orbitofrontal cortex plays a critical role in hedonic experience.
  • The proposed model offers a new framework for understanding OFC functions.
  • Further research into the OFC is essential for understanding human reward processing.