Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasticizers and their effects on microencapsulation process by spray-drying in an aqueous system.

L S Wan1, P W Heng, C G Chia

  • 1Department of Pharmacy, National University of Singapore.

Journal of Microencapsulation
|January 1, 1992
PubMed
Summary

Plasticizers significantly impact hydroxypropylmethylcellulose microcapsule properties. Citric acid and glycerin promote solid drug dispersion, while citric acid-containing microcapsules exhibit the slowest theophylline release.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Continuous dosing of a novel contraceptive vaginal ring releasing Nestorone® and estradiol: pharmacokinetics from a dose-finding study.

Contraception·2018
Same author

Surface hydrophilisation and antibacterial functionalisation for microporous polypropylene membranes.

Water science and technology : a journal of the International Association on Water Pollution Research·2010
Same author

The influence of microcrystalline cellulose grade on shape and shape distributions of pellets produced by extrusion-spheronization.

Chemical & pharmaceutical bulletin·2001
Same author

Investigation of the influence of mean HPMC particle size and number of polymer particles on the release of aspirin from swellable hydrophilic matrix tablets.

Journal of controlled release : official journal of the Controlled Release Society·2001
Same author

A study of the effects of the physical characteristics of microcrystalline cellulose on performance in extrusion spheronization.

Pharmaceutical research·2001
Same author

Endometrial brush biopsy for the diagnosis of endometrial cancer.

The Journal of reproductive medicine·2001

Area of Science:

  • Pharmaceutical Technology
  • Materials Science

Background:

  • Hydroxypropylmethylcellulose (HPMC) is widely used for microencapsulation.
  • Theophylline is a common bronchodilator requiring controlled release formulations.

Purpose of the Study:

  • To investigate the effect of various plasticizers on the properties of microencapsulated theophylline using HPMC.
  • To understand how plasticizers influence drug release, crystallization, and physical characteristics of microcapsules.

Main Methods:

  • Aqueous spray-drying technique was employed to prepare microencapsulated theophylline particles.
  • Various plasticizers including triethylcitrate, polyethylene glycol, propylene glycol, glycerin, and citric acid were evaluated.
  • Drug release profiles, crystallization behavior, and flow properties were analyzed.

Related Experiment Videos

Main Results:

  • Triethylcitrate, a water-insoluble plasticizer, resulted in porous microcapsules and rapid drug release.
  • Citric acid and glycerin induced solid drug dispersion, affecting drug crystallization.
  • Plasticizers influenced microcapsule cohesiveness and flow properties; citric acid, glycerin, and propylene glycol improved wall formation.
  • Microcapsules containing citric acid demonstrated the slowest drug release rate.

Conclusions:

  • Plasticizer selection is critical for controlling theophylline release from HPMC microcapsules.
  • Citric acid is a promising plasticizer for achieving sustained release of theophylline.
  • Plasticizers affect both the physical properties and drug release kinetics of microencapsulated formulations.