Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is mitotic chromatid segregation random?

C D Bell1

  • 1Division of Anatomical Pathology, Department of Laboratory Medicine, St.Michael's Hospital, Toronto, Canada. dbell@smh.toronto.on.ca

Histology and Histopathology
|September 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deconstructing the evolutionary complexity between rust fungi (<i>Pucciniales</i>) and their plant hosts.

Studies in mycology·2018
Same author

Rapid diversification of Tragopogon and ecological associates in Eurasia.

Journal of evolutionary biology·2012
Same author

The Value of X-Rays.

Journal of the National Medical Association·2010
Same author

Investigating potential for depensation in marine turtles: how low can you go?

Conservation biology : the journal of the Society for Conservation Biology·2009
Same author

Symmetry applied to nuclear microanatomy: a review of gene function and cell differentiation.

Histology and histopathology·2004
Same author

Histologic, immunohistochemical, and ultrastructural findings in a case of minocycline-associated "black thyroid".

Endocrine pathology·2002
Same journal

Age-related morphological and histological changes in the dromedary camel thymus.

Histology and histopathology·2026
Same journal

Isofraxidin ameliorates CCl<sub>4</sub>-induced liver fibrosis in mice by inhibiting the NF-κB pathway.

Histology and histopathology·2026
Same journal

FOXO3/HMOX1 axis promotes melanoma progression by regulating ferroptosis and immune escape.

Histology and histopathology·2026
Same journal

Immunohistochemical evaluation of CD44 expression and its correlation with clinicopathological factors and molecular markers (EGFR, STAT3, and lipid metabolism-related proteins) in oral squamous cell carcinoma.

Histology and histopathology·2026
Same journal

Betulinic acid mitigates septic cardiomyopathy in mice through modulating the TLR4/MyD88/NF-κB signaling axis and NLRP3 inflammasome pathway.

Histology and histopathology·2026
Same journal

Extension loss following ACL reconstruction: A narrative review of mechanisms and phase-specific management.

Histology and histopathology·2026
See all related articles

Sister chromatid segregation during cell division may not be random. Epigenetic differences and chromosomal territory changes suggest programmed segregation, impacting cellular differentiation.

Area of Science:

  • Cell Biology
  • Genetics
  • Epigenetics

Background:

  • Sister chromatids may possess epigenetic differences, influencing inheritance across cell generations.
  • Non-random chromosome segregation has been observed in meiosis I across various organisms.
  • Potential asymmetry in sister chromatids and their kinetochores during mitosis requires investigation.

Purpose of the Study:

  • To review existing literature for evidence of non-random chromatid segregation during mitosis.
  • To explore the role of epigenetic modifications and cell differentiation in centromere and kinetochore function.
  • To investigate the hypothesis that gene regulation depends on the proximity and interaction of genetic loci.

Main Methods:

  • Literature review of ultrastructural, immunohistochemical, and physiological studies on kinetochores.

Related Experiment Videos

  • Analysis of existing descriptions of non-random mitotic segregation.
  • Examination of studies on chromosomal territories and nuclear positioning.

    • Main Results:

    • Evidence suggests non-random homologue segregation in meiosis I, with implications for kinetochore heterochromatin.
    • Limited descriptions of non-random mitotic segregation exist, with potential asymmetry in sister chromatids.
    • Epigenetic changes and differentiation can influence centromeric and kinetochore function.
    • Chromosomal territories exhibit spatial changes related to function and differentiation, potentially showing asymmetry.

    Conclusions:

    • The possibility of non-random chromatid segregation at mitosis is supported by existing evidence.
    • Further experimental investigation is required to definitively answer whether mitotic chromatid segregation is programmed.
    • Understanding chromatid segregation is crucial for comprehending cellular differentiation and epigenetic inheritance.