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Updated: Aug 12, 2026

Improved Preparation and Preservation of Hippocampal Mouse Slices for a Very Stable and Reproducible Recording of Long-term Potentiation
Published on: June 26, 2013
Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity
1Volen Center for Complex Systems, Biology Department, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA. Lisman@brandeis.edu
Abstract:
Long-term potentiation and long-term depression require postsynaptic depolarization, which many current models attribute to backpropagating action potentials. New experimental work suggests, however, that other mechanisms can lead to dendritic depolarization, and that backpropagating action potentials may be neither necessary nor sufficient for synaptic plasticity in vivo.
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