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[Effect of Chinese traditional medicine mixture on inflammatory response in rats with severe burn]
Cheng-Qun Luo1, Jian-Da Zhou, Dao-Jin Chen
1Department of Burns and Plastics Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Objective:
To investigate the regulatory effect of Chinese traditional medicine mixture (CTMM) on inflammatory response in rats with severe burn.
Methods:
One hundred and ten rats were randomly divided into 3 groups:scalded rats inflicted by 30% III degree scald were treated with CTMM and SD-Ag (CTMM group), scalded rats inflicted by 30% III degree scald were treated with SD-Ag alone (scalded group), and healthy rats were treated with SD-Ag (normal group). The serum contents of TNF-alpha, IL-beta, IL-6, IL-8, IL-4, and IL-10 in rats in the 3 groups were dynamically monitored.
Results:
The serum contents of TNF-alpha, IL-1beta, IL-6, IL-8, IL4, and IL-10 evidently increased in both the CTMM and scalded groups. But the contents of pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6, and IL-8) in the CTMM group were much lower than those in the scalded group. However, the contents of anti-inflammatory cytokines (IL-4 and IL-10) in the CTMM group were much higher than those in the scalded group.
Conclusion:
CTMM has double-way regulatory effect on the inflammatory response in rats with severe burn.
