The possible etiopathogenic genes of Sjögren's syndrome
Masami Takei1, Hidetaka Shiraiwa, Takashi Azuma
1Department of Internal Medicine, Division of Hematology and Rheumatology, Nihon University, School of Medicine, Tokyo, Japan.
Abstract:
Sjögren's syndrome is a chronic autoimmune disease characterized by focal lymphocytic infiltration of lacrimal and salivary glands, but the precise mechanism of this syndrome is unclear. To clarify the pathogenesis of Sjögren's syndrome, the related genes must be identified. In the present study, we investigate the increased expression of genes and molecules related to Sjögren's syndrome and present our findings of cDNA microarray analysis in the mouse model. Furthermore, we present the results of immunohistochemical analysis of salivary glands in the mouse model and patients with Sjögren's syndrome. This approach might open a new discussion of the existence of principal pathogenic molecules in Sjögren's syndrome.
Related Concept Videos
Pleiotropy
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
Myasthenia Gravis ll: Pathophysiology
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
The JAK-STAT Signaling Pathway
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...

