Related Experiment Video
Updated: Aug 16, 2026

The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Selective serotonin reuptake inhibitors treatment effects on auditory measures in depressed female subjects
Kamakshi V Gopal1, Kelly A Briley, Elizabeth S Goodale
1Department of Speech and Hearing Sciences, University of North Texas, P.O. Box 305010, Denton, TX 76203, Texas, USA. gopal@unt.edu
Abstract:
The purpose of this study was to evaluate the auditory effects of selective serotonin reuptake inhibitors (SSRI), known to enhance serotonin (5-HT) transmission in the brain. The experimental group consisted of 14 clinically depressed female subjects, and the control group consisted of 11 non-depressed females. A battery of tests was administered to the experimental group while on and off of SSRI medication. The control group was also administered the test battery twice. Results indicated no significant differences in the control group between sessions. The experimental group showed significantly smaller transient evoked emissions, higher SCAN-A (auditory processing test) composite scores, and smaller amplitude growth functions for Auditory brainstem response peak V and Auditory late response peak N(1)P(2) while on SSRI medication. The increased 5-HT levels in the presence of SSRI (due to reduced reuptake of 5-HT) may be contributing to the significant changes seen in auditory measures with the experimental group.
Related Concept Videos
Antidepressant Drugs: MAOIs and Other Agents
Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
G-protein Coupled Receptors
Antidepressant Drugs: Overview
