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A novel 4.1 ezrin radixin moesin (FERM)-containing protein, 'Willin'
Frank J Gunn-Moore1, Gavin I Welsh, Lissa R Herron
1Schools of Biology and Medicine, University of St. Andrews, KY16 9TS, UK. fjg1@st-and.ac.uk
Abstract:
The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.
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