Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fetal hydrops.

P A Boyd1, J W Keeling

  • 1Department of Medical Genetics, Churchill Hospital, Headington, Oxford.

Journal of Medical Genetics
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

Non-immune hydrops fetalis, a serious condition, was frequently linked to chromosome abnormalities like 45,X and autosomal trisomy in a 1983-1988 study. Earlier diagnosis and increased detection of chromosomal causes were noted.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Crop Rotation, Cultivar, and Irrigation and Nitrogen Rate on Verticillium Wilt in Cotton.

Plant disease·2019
Same author

Trends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly: a registry-based study in 14 European countries 1984-2007.

BJOG : an international journal of obstetrics and gynaecology·2013
Same author

The evolution of prenatal screening and diagnosis and its impact on an unselected population over an 18-year period.

BJOG : an international journal of obstetrics and gynaecology·2012
Same author

Ambient air pollution and risk of congenital anomalies in England, 1991-1999.

Occupational and environmental medicine·2009
Same author

Effect of a Terminated Cover Crop and Aldicarb on Cotton Yield and Meloidogyne incognita Population Density.

Journal of nematology·2009
Same author

Survey of prenatal screening policies in Europe for structural malformations and chromosome anomalies, and their impact on detection and termination rates for neural tube defects and Down's syndrome.

BJOG : an international journal of obstetrics and gynaecology·2008
Same journal

Longest surviving patient with a homozygous splice-altering <i>EGFR</i> pathogenic variant presenting with skin autoinflammation and a Bartter-like salt-losing tubulopathy.

Journal of medical genetics·2026
Same journal

Functional characterisation and pathological significance of variants of <i>MEF2C</i> promoter in tetralogy of Fallot.

Journal of medical genetics·2026
Same journal

Identification of biallelic loss-of-function <i>PREP</i> variants in three individuals with syndromic intellectual disability.

Journal of medical genetics·2026
Same journal

Inherited retinal disease genes with dual inheritance patterns: insights from the IRD-PT registry.

Journal of medical genetics·2026
Same journal

Interpreting <i>TP53</i> variants: somatic mosaicism and <i>ERCC6L2</i>-driven clonal evolution.

Journal of medical genetics·2026
Same journal

Review of estimates of birth incidence and population prevalence over time and between countries of the rare neurodevelopmental condition Prader-Willi syndrome.

Journal of medical genetics·2026
See all related articles

Area of Science:

  • Perinatology
  • Medical Genetics
  • Fetal Pathology

Background:

  • Non-immune hydrops fetalis (NIHF) is a significant obstetric complication.
  • Understanding the etiology of NIHF is crucial for diagnosis and management.
  • Previous studies have identified various causes, including chromosomal abnormalities and infections.

Purpose of the Study:

  • To investigate the causes and associations of non-immune hydrops fetalis in a cohort of fetuses and neonates.
  • To compare the findings with a previous study period (1976-1982).
  • To assess trends in diagnosis and associated conditions.

Main Methods:

  • Retrospective review of 72 cases of NIHF diagnosed between 1983 and 1988.
  • Karyotyping and necropsy findings were analyzed.

Related Experiment Videos

  • Histological examination for infection was performed.
  • Comparison with data from 1976-1982.

    • Main Results:

    • Chromosome abnormalities were the most common association, identified in 22 cases (11 with 45,X, 11 with autosomal trisomy).
    • Infection was histologically confirmed in 11 cases.
    • Major structural anomalies were present in seven cases, and six affected fetuses were twins.
    • The proportion of undetermined causes decreased from 16% (1976-1982) to 8% (1983-1988).
    • Hydrops was diagnosed more frequently antenatally, before 20 weeks' gestation, and was more often associated with chromosomal anomalies compared to the previous period.

    Conclusions:

    • Chromosomal abnormalities are the leading cause of non-immune hydrops fetalis.
    • Improved diagnostic methods have led to earlier detection and a higher identification rate of chromosomal causes.
    • The study highlights a decrease in the proportion of unexplained hydrops cases over time.