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Related Experiment Videos

Corollary discharge dysfunction in schizophrenia: can it explain auditory hallucinations?

Judith M Ford1, Daniel H Mathalon

  • 1Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. judith.ford@yale.edu

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
|September 3, 2005
PubMed
Summary

Schizophrenia may involve faulty corollary discharge, a brain mechanism for distinguishing self-made from external perceptions. Studies found abnormalities in this system in patients, but linking it to hallucinations remains challenging.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • The corollary discharge mechanism helps differentiate self-generated from external sensory information.
  • Dysfunction in this system is hypothesized to contribute to positive symptoms in schizophrenia, such as auditory hallucinations.
  • While studied in vision, corollary discharge likely operates in auditory processing and potentially inner speech.

Purpose of the Study:

  • To investigate the corollary discharge system using neurophysiological measures.
  • To examine abnormalities in corollary discharge in patients with schizophrenia.
  • To explore the relationship between corollary discharge markers and auditory hallucinations.

Main Methods:

  • Utilized event-related potentials (ERPs) to assess corollary discharge during speech production.

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  • Measured EEG gamma band coherence between frontal and temporal lobes during talking and listening.
  • Introduced distorted auditory feedback during talking in healthy individuals to probe the system.

    • Main Results:

    • Demonstrated the corollary discharge phenomenon using ERPs during talking.
    • Found abnormal corollary discharge markers in patients with schizophrenia.
    • Observed increased frontal-temporal gamma band coherence during talking in healthy individuals, which was disrupted by distorted feedback; this pattern was absent in schizophrenia patients.
    • Limited success in correlating neurobiological indicators of corollary discharge with patient-reported hallucinations.

    Conclusions:

    • ERPs and EEG gamma coherence serve as indices for the efference copy/corollary discharge system.
    • Abnormalities in these neurophysiological markers are evident in schizophrenia.
    • Further research is needed to establish a definitive link between corollary discharge dysfunction and the experience of hallucinations in schizophrenia.