Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamics-based amplification of RNA function and its characterization by using NMR spectroscopy.

Hashim M Al-Hashimi1

  • 1Department of Chemistry and Biophysics Research Division, University of Michigan, Ann Arbor, MI 48109, USA. hashimi@umich.edu

Chembiochem : a European Journal of Chemical Biology
|September 3, 2005
PubMed
Summary

Ribonucleic acid (RNA) achieves functional diversity through controlled conformational changes. Understanding RNA structural dynamics is key to its cellular roles and function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing the contribution of rare DNA states to cancer mutational signatures using sequence-specific conformational fingerprinting.

Nature communications·2026
Same author

Thermodynamic prediction of RNA cellular activity from sequence via conformational ensembles.

Cell·2026
Same author

Revealing hidden protonated conformational states in RNA dynamic ensembles.

Nucleic acids research·2025
Same author

Probing rare and short-lived conformational states in nucleic acids using off-resonance carbonyl and guanidino carbon R<sub>1ρ</sub> relaxation dispersion.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2025
Same author

Kinetic Dissection of Proton-Coupled Conformational Transitions in Nucleic Acids by Integrating pH-Dependent NMR and Chemical Modifications.

Journal of the American Chemical Society·2025
Same author

Insight into the Conformational Ensembles Formed by U-U and T-T Mismatches in RNA and DNA Duplexes From a Structure-based Survey, NMR, and Molecular Dynamics Simulations.

Journal of molecular biology·2025

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Structural Biology

Background:

  • Ribonucleic acid (RNA) performs diverse cellular functions, raising questions about its functional versatility.
  • The limited number of nucleotide building blocks suggests complex regulatory mechanisms are involved.

Purpose of the Study:

  • To explore how RNA achieves functional diversity through conformational changes.
  • To examine the role of RNA structure and dynamics in achieving selectivity.
  • To review Nuclear Magnetic Resonance (NMR) techniques for studying RNA dynamics and function.

Main Methods:

  • Discussion of RNA conformational changes in response to cellular signals.
  • Analysis of pathways for selective conformational changes based on RNA structure and dynamics.

Related Experiment Videos

  • Review of solution-state Nuclear Magnetic Resonance (NMR) spectroscopy.

    • Main Results:

    • RNA gains mechanistic and chemical complexity via controlled conformational changes.
    • Selectivity in these changes depends on RNA's inherent structure and dynamic properties.
    • Solution-state NMR is a valuable tool for characterizing RNA structural dynamics.

    Conclusions:

    • Controlled conformational changes are central to RNA's functional diversity.
    • RNA structure and dynamics are critical for selective functional regulation.
    • NMR spectroscopy provides insights into the structure-dynamics-function paradigm of RNA.