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Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes

Wei Wu1, Sébastien Wieckowski, Giorgia Pastorin

  • 1Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France.

Angewandte Chemie (International Ed. in English)
|September 3, 2005
PubMed
Abstract

No abstract available in PubMed .

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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