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Primary endodermal sinus tumor of the penis: a case report
S S Alurkar1, B N Dhabhar, N A Jambhekar
1Department of Medical Oncology, Tata Memorial Hospital, Parel, Bombay, India.
The Journal of Urology
|July 1, 1992
Summary
This study details a rare penile germ cell tumor in a child, successfully treated with chemotherapy. The patient achieved a complete response and remains disease-free, highlighting effective treatment for this unusual cancer.
Area of Science:
- Pediatric Oncology
- Urologic Oncology
- Germ Cell Tumors
Background:
- Primary extragonadal germ cell tumors are rare, particularly in extragonadal sites like the penis.
- Endodermal sinus tumors (yolk sac tumors) are a type of germ cell tumor typically found in gonadal sites.
Observation:
- A 2-year-old child presented with a primary extragonadal germ cell tumor of the penis.
- Elevated serum alpha-fetoprotein levels were noted in the patient.
Findings:
- The patient received a combination chemotherapy regimen including bleomycin, etoposide, and cisplatin.
- A complete response was achieved within 3 cycles of treatment.
- The patient was alive and disease-free 8 months post-diagnosis.
Implications:
- This case represents the first reported instance of an endodermal sinus tumor of the penis.
- The findings suggest that standard chemotherapy regimens can be effective for this rare tumor.
- Further research into the histogenesis and management of penile germ cell tumors is warranted.