[Interaction between microbubbles and ultrasound. Present and future applications of contrast agents]

The way in which microbubbles (MB) increase the acoustic signal of blood was discovered incidentally during a hemodynamic study 30 years ago. Since then, new techniques and materials have been developed, looking for possible applications. Stability of MB has been increased, their size has been diminished, and interactions between MB and ultrasound have been understood. In this paper, we show the ways in which MB have been demonstrated or, at least, suggested to be useful in the fields of cardiological diagnosis and treatment.