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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Evidence based guidelines--a step too far?
Alyn H Morice1, Mark Parry-Billings
1Head of Academic Department of Medicine, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK. a.h.morice@hull.ac.uk
Abstract:
The growth of clinical guidelines has helped to improve the standard of patient care with the archetypal document being the British Thoracic Society's guidelines on asthma management. In recent years however the fashion has evolved to style guidelines according to the tenants of 'evidence based medicine'. We examine the evidence behind this fashion and conclude that there is a grave danger of bias and distortion of the data from this approach.
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